Molecular Nanomedicine Towards Cancer: 111 In-Labeled Nanoparticles
Identifieur interne : 001841 ( Main/Repository ); précédent : 001840; suivant : 001842Molecular Nanomedicine Towards Cancer: 111 In-Labeled Nanoparticles
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Abstract
Nanomedicine is the medical application of materials, devices, or systems in the nanometer scale and is currently undergoing explosive development. Molecular imaging of cancer using nanosized materials comprises an important part in diagnosis, therapy, and drug discovery in medical nanosciences. Radiopharmaceuticals are a key tool of molecular imaging in the field of nuclear medicine. The in vivo administration of radiolabeled nanoparticles (NPs) can provide an accurate biodistribution profile of the nanoformulations, as well as visualization of their route in vivo. Surface modifications of NPs with antibodies, peptides, or other small molecules that bind to tumor cell receptors have resulted in the development of sensitive and specific targeted imaging and diagnostic modalities for in vitro and in vivo applications. Radiometals are the most favorable of all radionuclides for labeling applications and they have the most suitable properties for single-photon emission computed tomography imaging. Indium-111 (111In), specifically, is a readily available gamma-emitting radiometal, which is widely used in clinical practice for diagnosis and/or therapy. Herein, we will overview the latest evolvement on 111In-labeled nanoparticles for biodistribution assessment and/or imaging evaluation of nanocarriers, as well as therapy in cancer.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Molecular Nanomedicine Towards Cancer: <sup>111</sup> In-Labeled Nanoparticles</title><author><name sortKey="Psimadas, Dimitrios" uniqKey="Psimadas D">Dimitrios Psimadas</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Nuclear Medicine, University Hospital of Larissa, Mezourlo</s1><s2>41110 Larissa</s2><s3>GRC</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>41110 Larissa</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Medical Instruments Technology, Technological Educational Institute of Athens</s1><s2>12210 Egaleo</s2><s3>GRC</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>12210 Egaleo</wicri:noRegion></affiliation></author><author><name sortKey="Georgoulias, Panagiotis" uniqKey="Georgoulias P">Panagiotis Georgoulias</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Nuclear Medicine, University Hospital of Larissa, Mezourlo</s1><s2>41110 Larissa</s2><s3>GRC</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>41110 Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Valotassiou, Varvara" uniqKey="Valotassiou V">Varvara Valotassiou</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Nuclear Medicine, University Hospital of Larissa, Mezourlo</s1><s2>41110 Larissa</s2><s3>GRC</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>41110 Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Loudos, George" uniqKey="Loudos G">George Loudos</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Medical Instruments Technology, Technological Educational Institute of Athens</s1><s2>12210 Egaleo</s2><s3>GRC</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>12210 Egaleo</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="inist">12-0267363</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0267363 INIST</idno><idno type="RBID">Pascal:12-0267363</idno><idno type="wicri:Area/Main/Corpus">001C03</idno><idno type="wicri:Area/Main/Repository">001841</idno></publicationStmt><seriesStmt><idno type="ISSN">0022-3549</idno><title level="j" type="abbreviated">J. pharm. sci.</title><title level="j" type="main">Journal of pharmaceutical sciences</title></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Distribution</term><term>Liposome</term><term>Malignant tumor</term><term>Medical imagery</term><term>Micelle</term><term>Nanoparticle</term><term>Nanotechnology</term><term>Pharmaceutical technology</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Nanotechnologie</term><term>Tumeur maligne</term><term>Nanoparticule</term><term>Imagerie médicale</term><term>Liposome</term><term>Micelle</term><term>Distribution</term><term>Technologie pharmaceutique</term></keywords><keywords scheme="Wicri" type="concept" xml:lang="fr"><term>Nanotechnologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Nanomedicine is the medical application of materials, devices, or systems in the nanometer scale and is currently undergoing explosive development. Molecular imaging of cancer using nanosized materials comprises an important part in diagnosis, therapy, and drug discovery in medical nanosciences. Radiopharmaceuticals are a key tool of molecular imaging in the field of nuclear medicine. The in vivo administration of radiolabeled nanoparticles (NPs) can provide an accurate biodistribution profile of the nanoformulations, as well as visualization of their route in vivo. Surface modifications of NPs with antibodies, peptides, or other small molecules that bind to tumor cell receptors have resulted in the development of sensitive and specific targeted imaging and diagnostic modalities for in vitro and in vivo applications. Radiometals are the most favorable of all radionuclides for labeling applications and they have the most suitable properties for single-photon emission computed tomography imaging. Indium-111 (<sup>111</sup>In), specifically, is a readily available gamma-emitting radiometal, which is widely used in clinical practice for diagnosis and/or therapy. Herein, we will overview the latest evolvement on <sup>111</sup>In-labeled nanoparticles for biodistribution assessment and/or imaging evaluation of nanocarriers, as well as therapy in cancer.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0022-3549</s0></fA01><fA02 i1="01"><s0>JPMSAE</s0></fA02><fA03 i2="1"><s0>J. pharm. sci.</s0></fA03><fA05><s2>101</s2></fA05><fA06><s2>7</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Molecular Nanomedicine Towards Cancer: <sup>111</sup> In-Labeled Nanoparticles</s1></fA08><fA11 i1="01" i2="1"><s1>PSIMADAS (Dimitrios)</s1></fA11><fA11 i1="02" i2="1"><s1>GEORGOULIAS (Panagiotis)</s1></fA11><fA11 i1="03" i2="1"><s1>VALOTASSIOU (Varvara)</s1></fA11><fA11 i1="04" i2="1"><s1>LOUDOS (George)</s1></fA11><fA14 i1="01"><s1>Department of Nuclear Medicine, University Hospital of Larissa, Mezourlo</s1><s2>41110 Larissa</s2><s3>GRC</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Medical Instruments Technology, Technological Educational Institute of Athens</s1><s2>12210 Egaleo</s2><s3>GRC</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></fA14><fA20><s1>2271-2280</s1></fA20><fA21><s1>2012</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>3209A</s2><s5>354000507989670010</s5></fA43><fA44><s0>0000</s0><s1>© 2012 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>65 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>12-0267363</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Journal of pharmaceutical sciences</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Nanomedicine is the medical application of materials, devices, or systems in the nanometer scale and is currently undergoing explosive development. Molecular imaging of cancer using nanosized materials comprises an important part in diagnosis, therapy, and drug discovery in medical nanosciences. Radiopharmaceuticals are a key tool of molecular imaging in the field of nuclear medicine. The in vivo administration of radiolabeled nanoparticles (NPs) can provide an accurate biodistribution profile of the nanoformulations, as well as visualization of their route in vivo. Surface modifications of NPs with antibodies, peptides, or other small molecules that bind to tumor cell receptors have resulted in the development of sensitive and specific targeted imaging and diagnostic modalities for in vitro and in vivo applications. Radiometals are the most favorable of all radionuclides for labeling applications and they have the most suitable properties for single-photon emission computed tomography imaging. Indium-111 (<sup>111</sup>In), specifically, is a readily available gamma-emitting radiometal, which is widely used in clinical practice for diagnosis and/or therapy. 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